Boost brain health and slow mental aging with 10 intriguing tips from longevity experts

Just as our bodies and organs break down as we age, so do our brains. 

While the cognitive aging process can’t be stopped, there are ways we can slow it down, according to Dr. Brett Osborn, a Florida neurosurgeon and longevity expert.

The key, he said, is sending the body “healthy signals” that prevent inflammation and reduce the “damage-inducing free radicals” that can wreak havoc on our cells and DNA.

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While there might not be “brain-specific” signals, the same healthy lifestyle choices that benefit the body will also apply to the brain, Osborn said.

Below are 10 of his top recommended changes you can make to slow brain aging and boost cognitive health.

1. Exercise regularly

Humans were born to move, Osborn said. And a sedentary lifestyle is a detriment to our bodies and our minds as well. 

“The brain not only sends movement instructions to the muscles, but also receives signals from the muscles,” he said. “This back-and-forth communication, from strenuous exercise in particular, forges neuron-to-neuron connections.”

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Exercise is particularly beneficial for the memory centers of the brain, he said.

“In patients with Alzheimer’s disease, hippocampal volume loss is lessened in those who exercise versus the sedentary group,” the doctor pointed out.

Physical activity also lowers levels of the stress hormone cortisol, Osborn said. This in turn helps to improve sleep, which rids the brain of toxins and forms memories. 

Osborn recommends engaging in 30 minutes of endurance training five days per week, or one hour of strength training three days per week and two 30-minute endurance training sessions.  

2. Get plenty of mental stimulation

Challenging your brain can help build “cognitive reserve,” which is the brain’s resistance to damage, Osborn noted. 

“These activities encourage neuronal firing in the temporal and parietal regions of the brain, critical areas for language and memory function,” he said. “Both functions are affected in patients with Alzheimer’s disease, so ‘exercising’ these brain areas is preservative.”

“The age-old adage applies here: Use it or lose it.”

Melanie Avalon, a health influencer, entrepreneur and biohacker based in Atlanta, agreed that mental stimulation is essential to maintaining brain health and resilience.

She recommended participating in “multifaceted, layered and complex activities.” 

“The age-old adage applies here: Use it or lose it.”

“Dancing, playing more difficult games, creating arts and crafts, and [engaging in] mentally stimulating occupational activities may support attention, working memory, task switching, mental speed and other characteristics linked to cognitive reserve,” Avalon said. 

“Such activities have also been found to correlate to increased gray matter volume in the brain.”

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Some other ideas from Osborn include doing puzzles, reading for 30 minutes nightly, learning a new language or picking up a musical instrument. 

He also suggested learning to identify (with your eyes closed) the distinct odors of 10 essential oils, which have been shown to have brain-protective effects. 

3. Eat a balanced diet

Nutrition plays a crucial role not only in the body, but also in brain health, Osborn said.

“Ideally, your diet should be low in sugar and refined carbohydrates, high in anti-inflammatory fats, and replete with colorful vegetables, particularly greens,” he told Fox News Digital.

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The doctor recommended sticking to a Mediterranean diet or a modified ketogenic diet with lots of olive and avocado oil, omega-3 fats from fish or flax, a moderate amount of protein from lean meats, and a lot of greens. 

“I eat blueberries and spinach religiously, as both promote healthy brain function,” he said.

For those who can’t stomach vegetables, he suggested building them into a smoothie or using a “super-food” powder as a drink fix. 

Protein intake should adequately support your muscle mass — 0.75 grams per pound of body weight, the doctor recommended. 

“It is a scientific fact that people with sarcopenia — reduced muscle mass and function — suffer not only physical but cognitive impairments,” Osborn said. “If you lose muscle as you age, your brain falters.”

“If you lose muscle as you age, your brain falters.”

Avalon also recommended intermittent fasting, a pattern of eating in which you restrict the hours you eat each day rather than the amount of food you eat, as a means of supporting cognitive function.

“During intermittent fasting, the brain can switch to utilizing ketones generated from fat as an additional fuel source, reducing its reliance on glucose,” she said. “This may be protective against cognitive decline.”

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Additionally, ketones produced during fasting trigger higher levels of proteins that help protect the brain and boost memory and learning, Avalon added.

4. Optimize your gut health

The gut has a robust network of nerves, and is therefore often called our “second brain,” Osborn noted.

“There is an intimate interaction between our GI tract and our brain, and the health of one parallels that of the other,” he said. “If your gut is healthy, often so is your brain.”

He noted, “If you eat properly, for example, you will produce optimal levels of serotonin that regulate appetite and mood.”

The vast majority of the body’s circulating serotonin — a neurotransmitter that conveys messages between the brain and the body — is produced by the gut, Osborn noted.

It’s also key to prevent chronic inflammation in the gut, which can cause the same condition in the brain. 

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Avalon noted that gut dysbiosis (an imbalance in the gut) is often seen in people with Alzheimer’s, and that amyloids created by the gut microbiome can even encourage the development of dementia. 

“Gut dysbiosis may also degrade sleep quality, itself a contributing factor to cognitive decline,” she said.

Osborn stressed the importance of avoiding fast food and sugary sodas, eating a lot of green leafy vegetables, and supplementing your diet with fermented foods such as kefir, sauerkraut, low-sugar yogurt or aged cheese, as these also promote intestinal health. 

5. Get enough quality sleep

Getting a restful night’s sleep is essential for memory formation, cognitive function and overall brain health, Osborn said.

“But here’s the issue: As we age, total sleep time, and particularly time spent in slow-wave sleep (SLS), declines,” he said.

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During SLS, you brain is washed free of cellular debris and toxins that have collected throughout the day, the doctor said.

“Those who sleep poorly are at a much higher risk for the development of Alzheimer’s disease,” Osborn said. “Amyloid plaques accumulate in those with Alzheimer’s disease and cause the brain to malfunction.”

To promote quality sleep, he recommended limiting screen time and exposure to blue light that interferes with the production of melatonin, the body’s sleep hormone.

“Those who sleep poorly are at much higher risk for the development of Alzheimer’s disease.”

Another tip is to reduce the ambient temperature of your bedroom — “65 to 70 degrees is optimal,” Osborn said.

He also suggested avoiding caffeine, alcoholic beverages and heavy meals before bed, which can disrupt sleep. 

Exercising regularly also helps to lower cortisol and facilitate sleep, Osborn added.

“The value of restorative sleep cannot be understated,” he added. “Your brain functions far more efficiently after a good night’s sleep.”

6. Manage stress levels

Chronic stress has detrimental effects on brain health, Osborn said. 

“While the body’s primary stress hormone, cortisol, plays a vital role in responding to short-term stressors, it can wreak havoc on the body in the long term,” he said. “Over time, high cortisol levels suppress the immune system, meaning a reduced ability to fend off infections.”

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Cortisol also elevates blood sugar, he added, which can lead to a variety of health problems, including insulin resistance and Type 2 diabetes, primers for Alzheimer’s disease.

To manage stress, Osborn recommended practicing relaxation techniques such as meditation, yoga or deep breathing.

7. Engage socially

Maintaining social connections and engaging in meaningful conversations can help keep your mind sharp, according to Osborn. 

“Social engagement has been associated with high quality of life and overall well-being, and inversely related to depressive-type behaviors,” he told Fox News Digital.

“Socialization is part of our humanness,” he went on. “It makes us feel good and is good for our brains.”

For better social engagement, Osborn advised skipping social media in favor of an old-fashioned phone call or in-person meeting. 

“There is no substitute for human-to-human interaction, which stokes the biochemical pathways of the brain and encourages the release of ‘feel-good’ hormones such as dopamine and serotonin.”

“There is no substitute for human-to-human interaction, which stokes the biochemical pathways of the brain and encourages the release of ‘feel-good’ hormones such as dopamine and serotonin,” he said.

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“Isolation does nasty things to our brains. It ages us. Humans, almost by definition, are social beings,” he said. “Our brains thrive on it — and not via Zoom or Facebook.”

8.  Limit alcohol consumption

Osborn described alcohol as a “neurotoxin that accelerates brain aging in a multitude of ways.”

“In addition to being toxic to neurons and interfering with cognition, alcohol disrupts the gut microbiome, the normally healthy microbes residing in the gut, causing inflammation that spreads throughout the body,” he said.

The doctor recommended limiting alcohol consumption, or preferably avoiding it altogether.

“I instruct my patients to reduce their drinking by 50% every six months until they are abstinent,” he said. 

Some experts, however, believe that moderate drinking may provide some brain benefits.

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As Avalon pointed out, the Mediterranean Intervention for Neurodegenerative Delay Diet (MIND Diet), created by researchers at Rush University Medical Center, includes one glass of wine per day to ward off neurodegenerative decline.

“A 2019 review of 28 systematic reviews analyzing the associations of alcohol and cognitive decline found that the majority of the studies indicated light to moderate alcohol intake associated with reduced diagnoses of cognitive impairment, as well as fewer mortalities due to dementia,” she said.

On the other hand, both chronic and irregular heavy alcohol intake were found in some reviews to cause cognitive impairment, she added.

9. Consider taking brain-boosting supplements

“Just as there are brain-boosting foods like spinach, blueberries, ginger and turmeric, there are a multitude of supplements that may better your brain performance, enhance learning and memory formation, and/or lower cortisol, which slows brain aging,” Osborn said.

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Below are just some of the brain-boosting supplements that Osborn uses:

• Omega-3 fatty acids
• Exogenous ketones (powdered beta-hydroxybutyrate)
• Caffeine
• Lion’s mane extract
• Creatine
• Gingko biloba
• Ashwagandha (KSM-66)

“Keep in mind that supplements are not FDA-approved,” Osborn said. “Some may work well for you and some will not.”

He noted, “As always, before adding anything novel to your current medication or supplement regimen, discuss it with your physician, as some may interfere with or reduce the efficacy of your current medications.”

10. Balance hormone levels

Hormones play diverse roles throughout the body, including the brain. 

“Sex hormones like testosterone, estrogen and progesterone enhance cognition and may protect the brain from insults like a traumatic brain injury,” Osborn said.

Optimal levels of estrogen are integral to brain function, he added.

“Low levels, as is the case with testosterone, are associated with ‘brain fog’ due to heightened inflammation in the brain,” the doctor said. “This similarly applies to thyroid hormone.”

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“Your brain simply does not work right when your hormone levels are suboptimal, but it doesn’t have to be this way.”

To naturally increase hormone levels in the body, Osborn recommends strength training regularly, getting adequate sleep, and eating a low-glycemic, anti-inflammatory diet with lots of healthy fats.

If the natural route doesn’t work, hormone replacement therapy (HRT) is another option, but it must be done under medical supervision.

“Do not be dismissive of the central effects of hormones and their potential to enhance cognition or prevent neurodegenerative disease,” Osborn said. “It is thought that Alzheimer’s disease is not only a state of insulin resistance in the brain, but also a progesterone-deficient state.”

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“While both mind and body tend to ‘malfunction’ as we age, the longer we stand on this earth, you can slow its rate of progression — or rather, regression,” the doctor concluded. 

“And it’s easier than you may believe. What keeps your body healthy, similarly keeps your brain healthy.” 

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